What are the neurological effects of levetiracetam as compared to carbamazepine in children with focal epilepsy?

Presenter: Rebecca Repasky Luke, M.D.

Link to PowerPoint Presentation: Journal Club Feb 2016

Clinical Question:

What are the neurological effects of levetiracetam as compared to carbamazepine in children with focal epilepsy?

Journal Club Article:

Jung da E, et al.  Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy.  Neurology. 2015 Jun 9;84(23):2312-9.

Methodology:

A total of 121 out of 135 screened  children (4-16 years) were randomly assigned to LVT or CBZ groups in a multicenter, parallel-group, open-label trial.  The study’s primary endpoints were defined as the end of 52 weeks of treatment, followed by analysis of changes observed in a series of follow-up neurocognitive, behavioral, and emotional function tests performed during treatment in the per protocol population.  Drug efficacy and tolerability were also analyzed among the intention-to-treat (ITT) population.

Study Conclusions:

Neither LVT nor CBZ adversely affected neuropsychological function in pediatric patients.  Both medications were considered equally safe and effective as monotherapy in children with focal epilepsy.

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